To systematically assess the efficacy of enriching qi，promoting blood circulation and dredging meridians therapy for treating diabetic peripheral neuropathy.Methods:A total of 8 databases(CNKI,Wanfang,VIP,CBM,Cochrane Library,EMBASE,PubMed ClinicalTrails.gov)were searched to identify all published randomized controlled trials of enriching qi,promoting blood circulation and dredging meridians herbs combined with western medicine for the treatment of diabetic peripheral neuropathy.The Revman 5.3 software was used for statistical analysis,and the risk of bias(ROB)table was used for quality evaluation.Results:A total of 23 RCTs were identified,including 1608 patients.The methodological quality of the included studies was low.Using activating qi,promoting blood circulation and dredging meridians therapy to treat diabetic peripheral neuropathy can significantly increase the total clinical efficacy ［RR=0.30,95%CI(0.24～0.36),reduce the Toronto score ［MD=-1.35,95%CI(-1.57～-1.13),P<0.000 01］,raise motor nerve conduction velocity of median nerve ［MD=3.45,95%CI(2.45～4.45),P<0.000 01］ and common peroneal nerve ［MD=2.99,95%CI(2.00～3.98),P<0.000 01］,and sense nerve conduction velocity of median nerve ［MD=3.27,95%CI(2.10～4.44),P<0.000 01］,and common peroneal nerve ［MD=3.43,95%CI(2.02～4.84),P<0.000 01］.The Meta-analysis indicated that the therapy can lower the level of high shear rate of whole blood ［MD=-0.72,95%CI(-0.98～-0.46)P<0.000 01］,and Whole blood low cut ［MD=-1.52,95%CI(-2.82～-0.21),P=0.02］.The cure time of the treatment group was better than that of the control group［RR=1.71,95%CI（1.49～1.97）,P<0.000 01］.A total of 19 studies clearly showed no adverse reactions among the 23 RCTs,4 studies showed adverse reactions.However,no serious adverse events occurred in all studies.Conclusion:Enriching qi,promoting blood circulation and dredging meridians therapy in the treatment of diabetic peripheral neuropathy can improve the efficacy,reduce the Toronto score,improve the symptoms of metabolic disorders and hemorheology.Due to the quality of included studies is low,which affects the reliability of efficacy,high-quality RCTs are needed to confirm such conclusion in the future.