Based on the holism of traditional Chinese medicine(TCM)and syndrome differentiation,“qi transformation theory” holds that qi transformation is the essence of human life activity.The key to the metabolic disorder of qi,blood and body fluid is the dysfunction of qi.The etiology and pathogenesis of endocrinic and metabolic diseases are complex,and the course of disease is prolonged.The disorder of qi,blood and body fluid metabolism is an important cause of endocrinic metabolic diseases,and its main position is in the lung,spleen and kidney.Western medicine often can only control indicators while having side effects to different extents.To treat endocrinic metabolic diseases from “qi transformation theory” is to focus on restoring the body's function of qi transformation in order to make the zang-fu viscera harmonious and yin yang balanced,so as to relieve symptoms quickly,prevent disease progression,maintain long-term stable indicators,and improve the quality of life of patients.Coming from Treatise on Cold Pathogenic Diseases,Wuling Powder is one of the representatives of transforming qi and promoting diuresis.With its rigorous and exquisite formula,it can treat endocrine and metabolic diseases by regulating the body's qi transformation function and improving the metabolism disorder of qi,blood and fluid.Combined with the modern research progress of protecting liver and kidney,regulating immunity,lowering blood sugar and lipid,and purine,it can be widely used in endocrine diseases,and the clinical effect is considerable.