Diabetes Kidney Disease(DKD)is the main cause of end-stage renal disease.According to the theory of combination of disease and syndrome,Professor NI Qing summarized clinical experience and proposed the treatment of DKD by combining disease with syndrome,by stages and steps.By differentiating the main syndrome,the subordinate syndrome,the indexes according to the stages of disease,the main prescription can be determined,with flexible increase or decrease of medicine,including single drug,drug pairs and drug trios.This formed a diagnosis-treat model of disease and syndrome combination.Professor NI Qing has achieved good clinical effect in treating DKD by combining disease with syndrome,by stages and steps.This diagnosis-treat model is coherent and comprehensive in consideration,which can be an excellent guidance for young physicians who have little clinical experience in traditional Chinese medicine.