The occurrence of diabetes is closely related to the imbalance of nutrient qi(ying)and defensive qi(wei).The pathogenesis of diabetes can be explained as a combination of blood deficiency,blood stasis,blood turbidity and blood toxin from ying qi,and of exogenous,obesity,emaciation and sedentary from wei qi.Guizhi Decoction,as “the chief of Zhongjing's prescription”,is specialized in treating diseases and syndromes of disharmony between nutrient qi and defensive qi.Combined modern pharmaceutical pharmacology with clinical research,Guizhi Decoction has the functions of two-way regulation of body temperature,hypoglycemia,anti-inflammatory,antibacterial,anti-virus,promoting sweat gland secretion,protecting cardiovascular system,improving cardiac function,regulating gastrointestinal peristalsis,etc.Guizhi Decoction can also be used in the treatment of diabetes related diseases with syndromes of disharmony between nutrient qi and defensive qi,such as diabetes with exogenous pathogens,diabetes with abnormal sweating function,diabetes with cardiac autonomic neuropathy and diabetes with gastrointestinal dysfunction.