To analyze the mechanism of the drug pair Coptis chinensis-Pueraria lobata in the treatment of type 2 diabetes mellitus(T2MD)by using the method of network pharmacology.Methods:The active components and target proteins of the drug pair Coptis chinensis-Pueraria lobata(C-P)were screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)，and the target proteins were screened by Unipro database and converted into gene names.The disease gene of T2MD was collected through GeneCards database.Then the drug-acting genes and disease-related genes were analyzed by vnne to find the intersecting targets，with which plus their corresponding active components an active component-target interaction network was constructed.GO function enrichment analysis and KEGG pathway enrichment analysis of the intersecting genes were also carried out.Results:A total of 13 active components acting on T2MD and 146 effect targets were identified，284 items were identified by GO functional enrichment analysis，and 77 pathways were identified by KEGG pathway analysis.Conclusion:The results of this study preliminarily discussed the basic pharmacological effects and mechanisms of C-P drugs on the treatment of T2MD,and laid a good foundation for further experimental research.