To investigate the clinical effect of oral Chinese medicine combined with conventional treatment on itchy skin.Methods:A total of 5 databases including CNKI,WanFang,CCD,Medline (Ovid Medline) and Embase were searched for a randomized controlled trial of oral Chinese medicine combined with conventional treatment for skin itching.Systematic evaluation and meta-analysis were performed using Revman 5.3.Results:A total of 32 randomized controlled trials were included,involving 2,750 subjects.Meta-analysis showed that oral Chinese medicine combined with conventional treatment can significantly reduce the pruritus symptom score ［SMD=-1.58,95% CI（-1.89 to -1.27）,P<0.000 01］.Compared with conventional treatment,oral Chinese medicine combined with conventional treatment can significantly reduce the score of pruritus symptoms ［SMD=-1.58,95%CI（-1.89 to -1.27）,P<0.000 01］,regardless of long-term treatment ［SMD=-1.19,95%CI（-1.76 to -0.62）,P<0.000 01］ or short-term treatment ［SMD=-1.71,95%CI（-2.08 to -1.34）,P<0.000 01］,patients with skin diseases ［SMD=-1.55,95%CI（-1.98 to -1.22）,P<0.000 01］ or patients with other diseases ［SMD=-1.61,95%CI（-2.18 to -1.04）,P<0.000 01］.Conclusion:Oral Chinese medicine can more effectively reduce the itching symptom score and relieve the symptoms of itchy skin.