The characteristics of traditional Chinese medicine (TCM) treatment against its syndromes determine that the treatment methods are often opposite in pairs，and the medicinal properties based on the treatment methods can also be divided in opposite directions.In this paper，the compatibility of opposite medicinal properties is changed from “opposite and mutually forming method” to “joint application of opposite TCM”，and the connotation of this methods and 6 representative forms are discussed:using tonification and drainage simultaneously，using cold and heat therapy simultaneously，using raising and descending simultaneously，using dispersing and contracting simultaneously，using moving and static simultaneously，using drying and moisturizing simultaneously.The author analyzes prescriptions of Treatise on Febrile and Miscellaneous Diseases，prescriptions of ancient China，ancient and modern medical records，and believes that except for prescriptions with very few species of medicine，“joint application of opposite TCM” is ubiquitous.The effect of opposite medicine is not offset by each other，but rather mutual restriction，running parallel，each plays its own effect.The more forms of this method are included in prescription，the wider the scope of clinical application is.It is especially important because this method covers 12 basic treatment rules.Therefore，we should take the initiative to use this rule to review prescription compatibility in clinical practice.Generally speaking，one of the 6 forms should be considered to avoid using the prescription of single property of a medicine at least.It is necessary to coordinate the overall proportion of the opposite medicines in the prescription according to the disease and syndrome.