To analyze the specific and common genes related to qi deficiency and blood stasis syndrome and yin deficiency and blood stasis syndrome of cerebral infarction by bioinformatics method，and to explore the mechanism of Sanqi Tongshu Capsule combined with butylphthalide in the treatment of blood stasis syndrome of cerebral infarction in order to provide theoretical basis for the prevention and treatment of cerebral infarction with combination of traditional Chinese and Western medicine.Methods:GEO chip data was analyzed，differential genes of qi deficiency and blood stasis syndrome was obtained and screened.From the perspective of PPI co-expression network，GO and KEGG enrichment analysis，the similarities and differences of the 2 blood stasis syndrome-specific genes were discussed.Sanqi Tongshu Capsules combined with butylphthalide active ingredient targets and blood stasis syndrome common gene integration was screened，and a common target of “drug-disease-syndrome” was obtained.Topological analysis focusing on core targets and parallel molecular docking，and common targets PPI network parallel enrichment analysis was constructed to explore the mechanism of Sanqitongshu Capsule combined with butylphthalide in the treatment of cerebral infarction with blood stasis syndrome.Results:A total of 2 092 differential genes of qi deficiency and blood stasis syndrome and 2 160 differential genes of yin deficiency and blood stasis syndrome of cerebral infarction were obtained，including 422 specific genes of qi deficiency and blood stasis syndrome，490 specific genes of yin deficiency and blood stasis syndrome and 1 670 common genes of blood stasis syndrome.Among them，there were 422 specific genes for qi deficiency and blood stasis syndrome，490 specific genes for Yin deficiency and blood stasis syndrome，and 1 670 common genes for blood stasis syndrome.Among them，the differential genes of qi deficiency and blood stasis syndrome and yin deficiency and blood stasis syndrome play a role through multi-component，multi-function，and multiple pathways.However，targets such as MMP-9 and EIF4A3 in qi deficiency and blood stasis syndrome have the strongest interaction，mainly through T cell receptors.In yin deficiency and blood stasis syndrome，EGFR，STAT3 and other targets have the strongest interaction，and they play a role through the ErbB signaling pathway.A total of 274 drug targets were screened and 32 common targets were obtained after integration of the common genes of blood stasis syndrome.After topological analysis，the core target SRC was focused.Hydrogen bond connection，mixed Pi bond connection and hydrophobic interaction were found to be the main action forms in molecular docking.The enrichment results of GO and KEGG showed that Sanqi Tongshu Capsule combined with butylphthalide mediated chemokine signaling pathway and cAMP signaling pathway in the form of multi-component，multi-function and multi-pathway in the blood stasis syndrome of cerebral infarction.Conclusion:The analysis of specific genes related to the 2 types of blood stasis syndrome reveals the enrichment characteristics of syndrome types and provides a basis for the related research of syndrome types.The analysis of the common target of “drug-disease-syndrome” reveals the possible general mechanism of Sanqi Tongshu Capsule combined with butylphthalide in the treatment of blood stasis syndrome of cerebral infarction，which provides basis for the treatment of cerebral infarction with the combination of traditional Chinese medicine and Western medicine.