To explore the molecular mechanism of Buzhong Yiqi Decoction in the treatment of stress urinary incontinence(SUI).Methods:Effective active ingredients and action targets of Buzhong Yiqi Decoction were retrieved with the aid of TCMSP while the disease targets were screened out using GeneGards and OMIM databases.The active ingredient of Buzhong Yiqi Decoction-target network and PPI network were established using Cytoscape 3.7.2 software.And then using R software the gene function of the target gene(Gene Ontology，GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis were annotated.Results:A total of 182 effective active ingredients of Buzhong Yiqi Decoction were obtained，and 116 potential targets can act on SUI.GO functional enrichment analysis obtained 2 115 GO itemsin total.KEGG pathway enrichment analysis obtained 20 pathways.Conclusion:Buzhong Yiqi Decoction mainly through quercetin，kaempferol,7-methoxy-2-methyl isoflavone,7-O-methyl isoeugenol，riccocodone，β-sitosterol，formonine，medicinal pterostilbene，naringin，sugar alcohol and other active ingredients regulates key targets of SELE，ICAM1，MMP3，MAPK14，CD40LG，PLAU，CCNA2，ERBB3，CASP1，and regulates AGE-RAGE in diabetic complications Signal pathways，bladder cancer signaling pathways，fluid shear stress and atherosclerosis signaling pathways，TNF signaling pathways，prostate cancer signaling pathways，pancreatic cancer signaling pathways，hepatitis B signaling pathways and other pathways so that SUI can be treated.