Radix Salviae Miltiorrhizae,as a kind of traditional Chinese medicine of promoting blood circulation for removing blood stasis,can be divided into water-soluble and fat soluble.Radix Salviae Miltiorrhizae has a unique protective effect on diabetic nephropathy (DN) clinically.According to analysis,Radix Salviae Miltiorrhizae through anti-oxidative stress response,inhibits the production of inflammatory mediators,regulates renal blood rheology,regulates glucose and lipid metabolism and other aspects to play its protective mechanism,so as to reduce blood sugar and blood lipids,reduce proteinuria,and reduce renal fibrosis and glomerular sclerosis and the purpose of protecting kidney function.