To explore the possible mechanism of intervention of Lycii Fructus in Retinitis Pigmentosa(RP)by using network pharmacology.Methods:By searching the officially published literature on the clinical efficacy of traditional Chinese medicine(TCM)prescriptions in the treatment of RP，the names and frequency of Chinese medicine used in the prescriptions were recorded.Compounds with oral bioavailability of 30% or more and drug likeness of 0.18 or higher in Lycii Fructus were screened as candidate drug-effect ingredients by TCMSP database，and then the target of active ingredients of Lycii Fructus were predicted according to “Related Targets” of TCMSP.The ingredients-target interaction network was constructed by Cytoscape 3.6.0.The genes for RP was searched by DrugBank and DisGeNET，and the STRING database protein interaction analysis was performed.The target of active ingredients of Lycii Fructus intersected with the target of RP through the Venny diagram，through which the key targets of effective active ingredients of Lycii Fructus to treat RP are obtained.DAVID was used to perform GO function annotation and KEGG pathway enrichment on key targets.Results:A total of 62 TCM prescriptions and 97 Chinese medicines were recorded.The most frequently used Chinese medicine was Lycii Fructus，which was used for 42 times.A total of 29 active ingredients，188 predicted targets，and 244 genes related to RP were identified，as well as 12 key targets of effective active ingredients of Lycii Fructus to treat RP.The targets were involved in regulation of gene expression，cell proliferation，RNA transcription regulation，angiogenesis，hypoxia，etc.The main pathways were PI3K-AKT signaling pathway and neurotrophin signaling pathway.Conclusion:Lycii Fructus may regulate optic nerve cell apoptosis and retinal neurodegeneration through PI3K-AKT signaling pathway and neurotrophin signaling pathway to protect visual function and achieve the purpose of treating RP.