To compare the content of water，extract，the dissolution rate of effective components，finger print，and stability in the boiling mode of traditional decoction pieces and infusing mode of cell-broken decoction pieces through the reasonable experimental design，in order to provide reference for clinical application of cell-broken decoction pieces.Methods:A total of 5 kinds of traditional Chinese medicine decoction pieces(Rhizoma Gastrodiae，Radix Angelicae Sinensis，Fructus Momordicae，Radix Codonopsis，Radix Notoginseng)and corresponding cell-broken pieces were selected to determine the content of water，extract，dissolution rate of effective components，finger print，and their stability according to the Pharmacopoeia method.The dissolution difference of components was compared under each own optimal process of dissolving.Results:The water content of each traditional decoction piece was higher than that of the cell-broken decoction piece; the extract content was basically the same; the dissolution of the cell-broken decoction pieces was was 55%～200% of that of traditional pieces.The finger print showed no significant difference between components dissolving out.The routine stability test for 12 months showed that except for the content of ferulic acid in Radix Angelicae Sinensis，other contents were basically stable.Conclusion:The water content of Chinese medicine cell-broken decoction pieces has its own new limit; the content of the extract of the two is basically the same; the dissolution of the effective components in cell-broken pieces is basically lower than that in the boiling pieces; the stability is basically stable within 12 months except for pieces with special components.It still has a great advantage to choose cell-broken pieces from the perspective of taking whole herb as medicine and convenience.