To explore the mechanism of Shenshuaiyin(SSY)in treatment of diabetic kidney disease(DKD)based on network pharmacology.Methods:Using a bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine(BATMAN-TCM)，traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP)，this paper screened effective components and predicted targets of SSY，searching GeneCards，TTD，DisGeNET to screen targets of DKD and using Venn online platform to get intersection targets of SSY-DKD.By using CytoNCA common targets of SSY-DKD was selected，and then a component-disease-target network was built using Cytoscape 3.7.1.Through DAVID database GO function enrichment and KEGG pathway enrichment was analyzed.Results:A total of 178 effective components and 280 potential targets of SSY were obtained based on BATMAN-TCM and TCMSP，2699 targets related to the occurrence and development of DKD were obtained while 31 common targets of SSY-DKD were obtained by using CytoNCA.A total of 346 items were obtained by GO function enrichment analysis，namely，278 biological process items，44 molecular function items and 24 cellular component items，mainly including means of functions such as response to oxidative stress，response to lipid，growth factor receptor binding，cytokine receptor binding，transcription factor binding，platelet alpha granule.KEGG pathway enrichment analysis obtained 101 items，including AGE-RAGE signaling pathway in diabetic complications，TNF signaling pathway，IL-17 signaling pathway，FoxO signaling pathway，MAPK signaling pathway.Conclusion:Based on network pharmacology，the overall regulatory characteristics of SSY in treatment of DKD were discussed and verified，and the potential mechanism of SSY in treatment of DKD was predicted，in order to provide scientific basis for the study of active ingredients and experimental research.