Meta-analysis of relevant domestic and foreign research literature on the treatment of advanced gastric cancer by the method of supplementing qi and activating blood combined with chemotherapy was carried out to evaluate the efficacy and safety of supplementary therapy of Yiqi Huoxue in the treatment of advanced gastric cancer.Methods:we collected randomized controlled studies related to the treatment of mid-advanced gastric cancer with the method of nourishing qi and activating blood，evaluated the methodological quality of the included studies according to the method recommended by the Cochrane Collaboration，and performed relevant statistical analysis on the measurement indicators of the included studies with RevMan 5.3 software.Results:A total of 12 studies were included and 933 patients were collected after screening.Meta-analysis showed therapeutic advantage of Yiqi Huoxue therapy combined with chemotherapy in the treatment of advanced gastric cancer has curative advantage in improving response rate ［OR=2.31,95%CI=(1.72 to 3.09)，Z＝5.63(P<0.000 01)］ and overall response rate ［OR=2.32,95%CI=(1.69 to 3.18)，Z＝5.20(P<0.000 01)］，improving rate of quality of life ［OR=4.17，95%CI=(2.75 to 6.30)，Z＝6.75(P<0.000 01)］，reducing the incidence of adverse reactions including the incidence of leukocyte decline ［OR=0.22，95%CI=(0.12 to 0.39)，Z＝5.17(P<0.000 01)］，nausea incidence ［OR=0.45，95%CI=(0.29 to 0.70)，Z＝3.55(P=0.000 4)］ and diarrhea incidence ［MD=0.32，95%CI=(0.20 to 0.51)，Z＝3.55,(P<0.000 01)］.In terms of improving immune NK it has the advantage of curative effects(RR=3.83，95%CI=(1.50 to 6.15)，Z＝3.23(P=0.001)］.It was better than chemotherapy alone.The difference was statistically significant.However,there was no significant advantage in improving the immune CD4/CD8 ［MD=0.49，95%CI=(0.30 to 0.67)，Z＝5.16(P<0.000 01)］.Conclusion:Yiqi Huoxue therapy combined with chemotherapy in the treatment of advanced gastric cancer is superior to the latter alone.However，in view of the generally low quality of the literature，at present，there is no reliable evidence to recommend the clinical treatment of the treatment of advanced gastric cancer with the method of replenishing qi and activating blood，and we look forward to further verification of high-quality RCT studies and further exploration of the mechanism.