The brain has the physiological functions of thinking，imagination，memory，intelligence，perception，motion perception and language.The root of spirit is in brain，and its action is controlled by heart，so mental activities are controlled by heart and brain.Brain disease involves the syndrome located in brain，disease syndrome of ophthalmology and otorhinolaryngology，coma or delirium related to the brain，the disease syndrome of unconsciousness or mental illness，and the disease syndrome related to abnormal motion perception.Brain disease due to depression syndrome refers to depression syndrome which is triggered or aggravated by emotional factors，such as partial headache，dizziness，tinnitus，buzzing in brain，inability to sleep，somnolence，forgetfulness，dementia，temporary smirking，depressive psychosis，manic psychosis，epilepsy，tremor，depression syncope，stroke，etc.Brain disease due to depression syndrome includes single depression syndrome as well as the coexistence of diseases and depression syndrome，diseases induced by depression syndrome as well as depression syndrome induced by diseases.It is necessary to treat brain disease due to depression syndrome from the aspect of depression，including the treatment from the liver，heart or kidney.More specifically，dispersing stagnated liver qi for relieving qi stagnation，clearing liver fire，calming endogenous wind and suppressing hyperactive liver，nourishing and emolliating liver，nourishing heart，clearing heart fire，sweeping phlegm and dispelling stasis and opening the orifices，tranquillization method，tonifying kidney and nourishing the marrow，coordinating heart and kidney，etc.