Programmed cell death-1 and its ligand (PD-1/PD-L1) inhibitors could cause immune-related adverse reactions different from previous treatments. According to the relevant knowledge of traditional Chinese medicine (TCM) basic theories and medicinal property theories, we try to analyze the Chinese herbal properties of PD-1/PD-L1 inhibitors and think that they are warm in four qi and pungent in five flavors, have the ascending and floating nature, and enter the lung, spleen and stomach meridians. The main etiology of immune-related adverse reactions is “immune drug toxicity”. The main pathogenies respectively are the exogenous pathogenic wind with dampness and heat toxicity which blocks the skin, the deficiency of spleen and stomach and the deficiency of qi and blood. Also, we propose the corresponding treatments in order to improve the clinical efficacy and safety of immunotherapy.