To analyze the mechanism of Xuefu Zhuyu Decoction in the treatment of coronary heart disease.Methods:GeneCards was used to obtain target genes related to coronary heart disease，Cytoscape 3.7.2 was used to draw a network diagram of “Chinese medicine components-disease target genes”，String database was used to construct a PPI network diagram，the PPI network diagram was imported into Cytoscape 3.7.2，and CytoNCA plug-in was used for network topology analysis.R64 3.6.1 was used software for GO function and KEGG pathway enrichment analysis of target genes.Results:A total of 224 related compounds of Xuefu Zhuyu Decoction were screened，and 3 564 related targets for coronary heart disease were screened.The PPI network showed that the top 10 target genes with degree value were IL6，AKT1，ALB，VEGFA，CCL2，EGF，IL1B，MMP-9，CASP3，MAPK1，topological analysis results showed that the top 10 target genes with degree value were PTGS2，MMP2，VEGFA，AKT1，ALB，CASP3，STAT3，IL6，MMP9，SERPINE1.GO enrichment analysis predicted that the treatment mechanism of this formula for coronary heart disease may be related to the regulation of nutritional level response，response to oxygen content，membrane rafts，membrane microdomains，phosphatase binding and other pathways.KEGG enrichment analysis predicted that the treatment of coronary heart disease by this prescription may achieve the curatie effects through several key pathways such as the AGE-RAGE signaling pathway，fluid shear stress and atherosclerosis，HIF-1 signaling pathway，and TNF signaling pathway.effect.Conclusion:This study explores the active components of Xuefu Zhuyu Decoction on coronary heart disease and its mechanism of action.Xuefu Zhuyu Decoction treats coronary heart disease through multiple targets and multiple pathways，which provides a theoretical basis for further research on the mechanism of action of the prescription.