To explore the medication rule of Chinese medicine master in the treatment of headache. Methods:Chinese medicine masters' prescription in the treatment of headaches were collected. “Traditional Chinese Medicine Auxiliary Platform System (V2.50)” were entered. Through the data mining method integrated in the system, the use of prescription drugs were analyzed, nature and flavor and channel tropism, core drugs, core drug pairs, and formulating rules were summarized, and the rules of traditional Chinese medicine masters for the treatment of constipation were classified. Results:The medicines used by national TCM masters to treat constipation were warm, calm, cold in nature, sweet, bitter, and pungent. Most of them belonged to the spleen and stomach meridian. The top 5 of the 30 high-frequency medicines selected were Radix Angelicae Sinensis, Fructus Aurantii Immaturus, and Fructus Cannabis, Rhizoma Atractylodis Macrocephalae, Radix Codonopsis. The most common drugs were tonic drugs, followed by qi promoting drugs and heat-clearing drugs. There were 15 drugs with a laxative effect, accounting for 50%; 15 drug combinations were obtained through the analysis of association rules, with 13 rules. Conclusion:In the treatment of headache, national Chinese medicine masters usually take Rhizoma Ligustici Chuanxiong as the core drug. The main moisturizing medicine is used to moisturize the large intestine. It also take care of the spleen and stomach, and regulate the qi. For those with chronic diseases and stubborn secrets, it is necessary to re-use moisturizing drugs, or appropriately purging or remove blood stasis and laxation, or treat them from it, which is flexible and changeable. Biantong Capsule treats the essence, blood and body fluid together. The liver, spleen and kidney are in harmony. It is the essence of national TCM masters. It is suitable for treating constipation caused by deficiency of essence, blood deficiency and intestinal dryness, spleen deficiency and stagnation of qi and heat. The elderly have more essence, blood, and deficiency of yang and qi. The prevention and treatment with Biantong Capsules is right and good.