To analyze the action mechanism of Jiaotai Pills in the treatment of arrhythmia by network pharmacology and molecular docking.Methods:The active components and their target genes of Rhizoma Coptidisn(黄连) and Cortex Cinnamomi(肉桂) were obtained through TCMSP platform and BATMAN database，GeneCards database retrieval were used to get the target genes associated with arrhythmia.Cytoscape software was used to draw “active ingredient-action target ” network graph.The STRING database was used to construct protein-protein interaction(PPI) network diagram of Jiaotai Pills in the treatment of arrhythmia.PPI network diagram was imported into Cytoscape.The DAVID database was used to perform GO(Gene Ontology) function and KEGG(Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis on drug-disease intersection targets，and Autodock Vina and Pymol were used for molecular docking.Results:A total of 31 active components and 556 component targets of Jiaotai Pills were collected.There were 2 205 targets related to arrhythmia; 174 drug and disease intersection targets were obtained; The Cytoscape topological analysis was used to obtain 20 core components such as berlambin，epiberberine，palmatine，obacunone，berberine and etc.and PPI network was used to obtain 15 core targets such as ALB,AKT1，MAPK3，VEGFA，SRC.A total of 821 GO terms and 109 KEGG pathways were obtained through bioinformatics enrichment analysis，mainly involving PI3K-AKT signaling pathway，Rap1 signaling pathway，cAMP signaling pathway，thyroid hormone signaling pathway，HIF-1 signaling pathway，etc.The results of molecular docking showed that the main active components had strong affinity with the core target(ALB，AKT1，MAPK3，VEGFA，SRC).Conclusion:This study revealed the mechanism of Jiaotai Pills in the treatment of arrhythmia by regulating cellular metabolism，reducing oxidative stress，improving vascular remodeling，providing some pharmacological basis for the follow-up study on the treatment of arrhythmia by Jiaotai Pills.