To explore the material basis and molecular mechanism of Actinidia root in the treatment of gastric precancerous lesions by network pharmacology.Methods:The network database was used to search and screen the root component targets and gastric precancerous lesions targets.Cytoscape3.7.2 software was used to construct a network of Chinese medicinal components-targets network; The protein-protein interaction network (PPI) of Actinidia root for the treatment of gastric precancerous lesions was constructed by using STRING database.We found the core target through topological analysis.Finally,the biological pathway and enrichment analysis of drug-disease intersection targets were carried out.Results:A total of 6 active ingredients and 218 target spots of Actinidia arguta root and 222 targets for gastric precancerous lesions were collected; there were 178 common targets for drug components and diseases.Topological analysis was carried out with a Degree value greater than 2 times (31.30),and 4 key core targets were finally obtained：VEGFA,IL6,EGFR,TP53; Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that Actinidia root had the largest number of targets in cancer pathways for the treatment of gastric precancerous lesions.The second was PID-ATF2 signaling pathway,biological process of muscle cell proliferation,fluid shear stress and atherosclerosis pathway.Conclusion:Actinidia root has the characteristics of multiple components,multiple targets and multiple pathways in the treatment of gastric precancerous lesions,and its mechanism is more complex,which may be realized mainly by participating in the regulation of cancer pathway.It is of great significance to analyze the material basis and molecular mechanism of Actinidia root in the treatment of gastric precancerous lesions by network pharmacology.