To summarize the therapeutic law of qi-yin deficiency syndrome in coronary heart disease (CHD).Methods:The clinical literature of the treatment of qi and iin deficiency of CHD with traditional Chinese medicine (TCM) in the past 20 years was searched,and the prescription medication law was used with the tools of EXCEL,SPSS 25.0 and SPSS Modeler 18.0 and other tools.Results:A total of 126 papers met the inclusion criteria,including 94 prescriptions,131 Chinese medicinal and 1 196 times of use were adopted.The main drugs were acrid,sweet and isothermal drugs and bitter and sour drugs,mainly enters the Heart Channel.The 3 kinds of Chinese medicinal which were used frequently were tonifying drugs,activating blood circulation to remove blood stasis,and heat-clearing drugs.The 5 kinds of Chinese medicinals which were used more frequently were supplementing qi deficiency drugs,heat-clearing drugs,activating blood to remove blood stasis drugs,regulating qi and relieving exterior symptoms drugs.Radix Ophiopogonis and Radix Glycyrrhizae were used in the first 2 places frequently.Radix Salviae Miltiorrhizae and Rhizoma Chuanxiong were used in the first 2 places frequently.Radix ophiopogonis-fructus schisandrae Chinensis were the most frequently used and mostly supported drug combination.Conclusion:The clinical application of tonic drugs,blood-activating and stasis-removing drugs,heat-clearing drugs,flexible compatibility with qi-regulating drugs,anti-exterior drugs,astringent drugs and hemostatic drugs can significantly improve the curative effect of CHD with qi-yin deficiency syndrome.