To analyze the relationship between monocyte to high-density lipoprotein cholesterol ratio(MHR)with blood-stasis syndrome(BSS)in coronary heart disease(CHD).Methods:A total of 180 CHD inpatients admitted to China-Japan Friendship Hospital from January 2018 to July 2018 were selected as the research objects and were divided into a BSS group(118 cases)and a non-BSS group(62 cases)according to the score of BSS in CHD.A total of 55 participants with non-CHD and non-BSS were recruited as control group.The levels of MHR was compared among 3 groups.Logistic regression was used to analyze the relationship between MHR and BSS score.And receiver operating characteristic(ROC)curve was drawn to evaluate the ability of MHR to diagnose BSS of coronary CHD.Results:The levels of MHR in the BSS group was significantly higher than non-BSS group and control group(P<0.01)，but there were no statistical difference between non-BSS group and control group(P>0.05).Logistic regression analysis showed that MHR was an independent risk factor for BSS in CHD [HR:0.903，95%CI(0.826 to 0.988)，P=0.026].ROC curve analysis demonstrated that the optimal cut-off value of MHR to diagnose BSS in CHD were 14.15，sensitivity of 83.9%，specificity of 68.6% [area under the curve(AUC)0.609，95%CI(0.521 to 0.696); P=0.017].Conclusion:MHR is an independent risk factor for BSS in CHD，which suggests that lipid-driven inflammation may be one of the pathological mechanisms of BSS in CHD.