To explore the effects of Yiqi Yangyin Formula in the treatment of acute myeloid leukemia (AML) and the influence on patients' hemogram and myelogram.Methods:A total of 77 AML patients were selected as the research objects and were divided randomly into a control group (n＝38) and an observation group (n＝39).The control group received conventional chemotherapy,and the observation group treated with Yiqi Yangyin Formula.The cellular immune status and serum VEGF,TGF-β1 levels,blood and bone marrow indicators were detected before and after treatment in the 2 groups,and the total clinical remission rate (ORR) and the incidence of adverse reactions were detected.Results:The proportion of whole blood CD3+,NK in control group decreased 2 courses after treatment than those before treatment,while those in observation group were higher than those before treatment and control group,the difference was statistically significant (P<0.05).The proportion of whole blood CD4+ and CD4+/CD8+ in observation group increased than those before treatment and control group,the difference was statistically significant (P<0.05); the ratio of CD8+ was lower than before treatment and the control group,and the difference was statistically significant (P<0.05); after treatment,the level of complete blood white blood cell (WBC) and the proportion of bone marrow blasts in the 2 groups gradually decreased,and the observation group was lower than the control group,the difference was statistically significant (P<0.05).After treatment,the complete blood platelet count (PLT) and hemoglobin (Hb) levels of the control group gradually decreased,and the observation group first decreased and then increased.And the observation group was higher than the control group,the difference was statistically significant (P<0.01); the serum vascular endothelial growth factor (VEGF) of the 2 groups after treatment was lower than that before treatment,and the observation group was lower than the control group,the difference was statistically significant (P<0.05),TGF-β1 was higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant (P<0.05); after treatment,the clinical ORR of the observation group was higher than the control group,and the difference was statistically significant (P<0.05); there was no significant difference in the incidence of adverse reactions between the 2 groups (P>0.05).Conclusion:Yiqi Yangyin Formula could enhance the cellular immune function of AML patients,improve the hematopoietic function,inhibit the proliferation of AML cells,and the ORR is better than that of chemotherapy alone.