Myocardial injury caused by sepsis is one of the leading causes of death in patients with sepsis in intensive care units.Studying the model of myocardial injury induced by Lipopolysaccharide（LPS）and exploring the therapeutic methods and strategies for myocardial injury can provide experiment basis for clinical treatment of myocardial injury induced by sepsis.Autophagy is generally considered to be a regulatory mechanism that degrades excess and damaged cell components to realize material recycling and reuse，and plays an important regulatory role in protecting the structure and function of cardiomyocytes.The latest research has found that autophagy imbalance is the key mechanism leading to cardiotoxic damage.The regulation of autophagy can improve myocardial damage caused by LPS.This paper aims to systematically sort out the mechanism of autophagy signaling pathway in myocardial injury caused by LPS and the research progress of traditional Chinese medicine treatment，and provide new ideas and methods for the treatment of myocardial injury caused by sepsis.