To analyze the characteristics of She medicines derived from plants in the Labiatae family, and to explore the guiding value of their special effects for later research. Methods:Through the analysis of literature information, the information about the medicinal parts, the cross-use of multiple ethnic groups, especially its different efficacy relative to the Traditional Chinese medicine were obtained, and then the network pharmacology method was used to explore the diseases and KEGG pathways related with typical Chinese-She medicine by cluster and enrichment analysis, respectively, indicating the scientific nature of the differential efficacy of She medicine. Results:A total of 25 She medicine from Labiatae plants were obtained, of which 19 were used as the whole medicinal section. There were cross-uses with 39 ethnic minorities, including Tujia, Yao, Miao, Dong, Zhuang and Yi ethnic groups with a high frequency of cross-use. Due to the living environment, She medicines from Labiatae plants were mainly used for exogenous seasonal diseases, traumatic diseases, female reproductive diseases, sore diseases, pediatric miscellaneous diseases and febrile diseases. Leonurus japonicus Houttuyn was a typical cross-used She medicine. Doctors from She ethnic group believed that Leonurus japonicus can treat colds with abdominal pain and thirst in the postpartum months, which was consistent with the results of network pharmacology. Conclusion:She medicines from Labiatae plants have high clinical application value, especially the records of its differential efficacy, which have high reference value for later research. But its overall research level is still relatively backward, and it needs to be further strengthened in the later research work on pharmacodynamics, material basis and mechanism of She medicine based on its record of differential efficacy.