gZav-Grib disease is a common and multimorbidity disease, the clinical efficacy of Tibetan medicine for the treatment of gZav-Grib disease is significant by still controversial. In order to promote and improve the understanding of the etiological mechanisms of human diseases, we reviewed ancient literature and found that gZav-Grib disease is a disorder of human blood proliferation after the loss of balance, increased human blood loss, and increased blood viscosity with the opposing effects of brodifacoum. The phenomenon of blood clogging or spillover occurs, which leads to damage to the white and black veins and then causes symptoms such as hemiplegia and aphasia, while the syndromic classification of gZav-Grib disease is summarized and combed according to the literature. Based on the theory of Tibetan medicine and relevant literature from inside and outside China on the frontiers of Tibetan medicine, the strategy of Tibetan medicine to intervene in gZav-Grib disease from neurovascular unit, chronopharmacology, metabolomics, and intestinal flora has been proposed, which may provide an adaptor point for the theory of Tibetan medicine to intervene in gZav-Grib disease by new methods and ideas.