Through the network pharmacology, we analyzed the mechanism of compound Yindan Decoction in the treatment of cholestatic hepatitis systematically. Methods:We screened out the active components and their effective targets in compound Yindan decoction by TCMSP and TCMID database. We obtained the disease-related targets of cholestatic hepatitis relying on GeneCards and OMIM databases. We intersected the drug and disease targets to obtain potential targets. We analyzed the protein types of potential targets relying on DisGenet database. We constructed the regulatory network of Chinese medicinal through Cytoscape3.8.0 software. We established the Protein interaction network (PPI) through the STRING database and brought into Cytoscape3.8.0 software for topological analysis. We established gene ontology (GO) enrichment analysis of potential targets and the Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis through Cytoscape software. GO enrichment analysis of potential targets and KEGG pathway enrichment analysis were performed by using R software. Results:The targets corresponding to the active components of compound Yindan Decoction intersected with the targets of cholestatic hepatitis. And we obtaineda total of 83 potential targets. Through compound regulation network construction, it was predicted that Herba Artemisiae Scopariae (virgate wormwood herb, YC), Radix et Rhizoma Rhei (rhubarb root and rhizome, DH), Fructus Gardeniae（cape jasmine fruit，ZZ）, may play roles in the treatment of cholestatic hepatitis through NOS2, ESR1, DPP4, etc. respectively relying on the construction of the compound regulatory network. Through the PPI interaction network and topological analysis, we found 11 core targets:Interleukin 6, protein kinase, vascular endothelial growth factor A. They may play major roles in the treatment of cholestatic hepatitis with compound Yindan Decoction. Through KEGG enrichment analysis, we predicted the role of potential targets in liver injury, inflammatory response, cellular metabolism and immune function of cholestatic hepatitis; The results of KEGG enrichment analysis predicted that Thl7 cell differentiation pathway and HIF-1 signaling pathway could regulate metabolic stress and inhibit inflammatory factors. Conclusion:The mechanism of compound Yindan Decoction in the treatment of cholestatic hepatitis may be related to its 109 active components, 11 core targets, Th17 cell differentiation, HIF-1 signaling pathways and etc.