To investigate the regulation of energy metabolism with Danqi Tablet in a rat model of ischemic heart diseaseMethods:A rat model of ischemic heart was established by ligation of the left anterior descending coronary arteryA total of 48 rats were divided into a sham an operation group，a Danqi tablet group and trimetazidine group，with 12 rats in each groupRats in the Danqi Tablets were given a solution of Danqi Tablets at a dose of 5000 mg/kgRats in the trimetazidine group were given a solution of trimetazidine at a dose of 60 mg/kgThe other groups were given normal salineAfter 1 month of treatment，cardiac function，myocardial tissue cytopathological changes，myocardial ATP levels，and AMPK/SIRT1/PGC-1α signaling pathway and downstream molecular expression were evaluatedResults:Echocardiography showed that compared with the model group，LVIDs and LVIDd in the Danqi tablet group were reduced by 2635% and 2073%，while EF and FS increased by 3161% and 4282%，and the difference was significant(P<005)The results of HE staining showed that the cardiomyocytes in the Danqi tablet group were arranged neatly，the cell edema was reduced，the cell gap was reduced，and the inflammatory cells were decreasedCompared with the model group，the myocardial ATP level of the Danqi tablet group increased significantly(P<005).Immunohistochemical staining showed that the PGC-1α positive staining score of rats in the Danqipian group was significantly higher than that of the model group(P<005)Western Blotting showed that the expression levels of AMPK，SIRT1，PGC-1α，MFN1，MFN2 and SOD2 were significantly increased in the Danqi Tablets group compared with the model group(P<005)Conclusion:Danqi Tablet can play a cardioprotective function in the rat model of ischemic heart disease and up-regulate ATP productionDanqi Tablets activate the AMPK/SIRT1/PGC-1α signaling pathway and its downstream molecules，improve energy metabolism and also regulate mitochondrial biogenesis，thereby improving rat cardiac function and preventing myocardial damage.