To explore the mechanism of Qiangli Dingxuan Tablets in the treatment of hypertension based on network pharmacology and molecular docking.Methods:Active components of Qiangli Dingxuan Tablets were searched by TCMSP and BATMAN-TCM，and the target prediction of the active components was made by Swiss Target Prediction database.Hypertension-related targets were obtained through GeneCards，OMIM and TTD databases，and drug targets and disease targets were integrated to obtain intersection targets.Cytoscape software was used to construct the drug-active ingredient-action target-disease network diagram and screen the core components.STRING platform was used to construct the PPI network and screen the core proteins.MCODE was used to perform protein clustering analysis of PPI network.DAVID database was used to analyze the enrichment of KEGG pathway.GO enrichment analysis was carried out by using Hiplot analysis platform.Autodock Vina and Pymol were used to realize the molecular docking of core component-core protein.Results:A total of 44 active components，679 action targets，2367 disease-related targets and 305 drug-disease intersection targets were retrieved.KEGG analysis showed that the overlapping genes were mainly concentrated in PI3K-AKT signal pathway，Ras signal pathway，Rap1 signal pathway，calcium signal pathway，cAMP signal pathway，HIF-1 and other signal pathways.GO analysis showed that the overlapping genes were mainly concentrated in the regulation of circulatory system，the regulation of vascular diameter，the positive regulation of MAPK cascade，the regulation of blood pressure and so on.The results of molecular docking showed that the main core components and core proteins had good binding activity.Conclusion:Qiangli Dingxuan Tablets may play a role in lowering blood pressure by regulating and controlling renin-angiotensin-aldosterone system，vascular smooth muscle contraction，oxidative stress，calcium channel and other systems.