To analyze Professor LYU Renhe's prescription in treating hyperuricemia，and summarize the relevant medication rules for the treatment of hyperuricemia.Methods:Frequency analysis，cluster analysis，and association rule analysis were used to analyze the 177 prescriptions.Results:Among the 177 prescriptions，124 single-flavored drugs were involved.The most frequently used drugs were Radix Salviae Miltiorrhizae(98.39%)，Polyporus Umbellatus(76.61%)，Rhizoma Ligustici Chuanxiong(65.32%)，and their doses are 20～60 g，20～30 g，10～15 g.After classifying the drugs，they were sorted according to the frequency of medication，in order:tonic medicine(22.95%)，heat-clearing medicine(16.39%)，blood-activating stasis medicine(14.75%)，etc.Cluster analysis and association rule analysis yielded 5 pairs of commonly used drug combinations，sorted by confidence，they were Angelica-Astragalus，Moutan Cortex-Red Peony，Yinchen-Gardenia，Weilingxian-Smilax，Chuanxiong-Salvia.Conclusion:Professor LYU Renhe commonly use tonic medicine，clearing heat medicine and activating blood and removing blood stasis medicine in clinical treatment of hyperuricemia，attach importance to pathogenesis of deficiency loss，internal heat and blood stasis of hyperuricemia，and use targeted drug compatibility treatment.