To clarify the core targets and pathways of Duhuo Jisheng Decoction for lumbar disc herniation by constructing a biological predictive model of “prescription-target gene-disease” of Duhuo Jisheng Decoction for intervening lumbar disc herniation.Methods:Firstly，by searching the target predicting function in the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)，the chemical component and targets of Duhuo Jisheng Decoction were collected，and the UniProt protein database was used to determine the gene target abbreviations; Secondly，the disease targets of lumbar intervertebral disc herniation were retrieved through the disease databases，including OMIM，DisGeNET，CTD，etc.Finally，the core targets of traditional Chinese medicine compound prescriptions and diseases were extracted with the help of the protein interaction analysis platform of STRING database and the topological analysis function of Cytoscape to obtain the network of “prescription-target gene-disease”.R language was used to perform GO and PPI analysis of KEGG，determining the core target and key pathway of Duhuo Jisheng Decoction in the intervention of lumbar disc herniation.Results:A total of 202 effective chemical components and 276 potential gene targets of Duhuo Jisheng Decoction were screened out，of which 88 are common target genes for lumbar disc herniation.PPI network analysis found that AKT1，IL6，JUN，MAPK，VEGFA，and IL1B are the core targets of Duhuo Jisheng Decoction in the intervention of lumbar disc herniation.GO enrichment analysis identified 107 enrichment items，mainly related to protease activation，cytokine binding，DNA binding transcription and RNA polymerase Ⅱ specific enrichment morphology; KEGG pathway annotation and enrichment analysis screened out 153 protein pathways related to Duhuo Jiesheng Decoction and the pathways with the highest differential protein expression include chronic inflammation pathway IL-17，pro-inflammatory pathway TNF，and the apoptosis signal transduction pathway.Conclusion:Duhuo Jisheng Decoction is scientifically rigorous in compatibility with comprehensive target coverage，which embodies the scientific connotation of TCM syndrome differentiation and treatment and modern medical “precision treatment”.Duhuo Jisheng Decoction acts on lumbar intervertebral disc herniation through multiple targets and multiple pathways.It mainly plays the role of anti-inflammatory immunity and cell repair.Further research from aspects of the molecular，animal，and clinical practice are needed，with the help of computing technology，in vivo，and in vitro to innovate for clinical prescriptions.