To explore the the common key target and signaling pathway of Simiao Yong'an(SMYA) Decoction in treating atherosclerosis and thromboangiitis obliterans by bioinformatic analysis.Methods:The active compounds and corresponding targets of 4 traditional Chinese medicines from SMYA Decoction were obtained by database mining and retrieval.The associated targets of AS and TAO were screened by GeneCards，CTD and NCBI database.Venny 2.1 was used to obtain the common targets of the two diseases of drug action.The PPI network of common target proteins was constructed through STRING database.Cytoscape 3.7.2 software was used to construct drug-active compound-common target-disease global regulatory network diagrams.The GO classified enrichment analysis and KEGG pathway enrichment analysis were performed using Bioconductor platform.Results:The common targets of SMYA Decoction in As and Tao were mainly 47，including VEGFA，IL6，Jun，TNF，FOS，MAPK8，MMP9，IL10，ICAM1，etc.A total of 9 active components，mainly flavonoids and sterols，were screened out.These targets were enriched by KEGG pathway and participate in the regulation of multiple pathways such as AGE-RAGE signaling pathway in diabetic complications，TNF signaling pathway，fluid shear stress and atherosclerosis，human cytomegalovirus infection，apoptosis，T cell receptor signaling pathway.Conclusion:The pharmacological effects of SMYA Decoction through anti-inflammation，reducing plaque formation and immune response，changing blood flow changes and other biological pathways have confirmed its multi-component，multi-target and multi-pathway regulatory characteristics.Simultaneously，the study has predicted the potential molecular mechanism for the “same treatment for different diseases” of AS and TAO，and provided theoretical basis for experimental design and further research in traditional Chinese medicine.