Varicocele is a common disease in male urology clinic，mainly manifested as testicular pendent distension discomfort，scrotal moisture，less weak semen and other symptoms.There is no specific drug in clinical treatment of modern medicine and traditional Chinese medicine.Mailuo Shutong Pills was created by TANG Zuxuan，a Chinese medical master，for the treatment of damp and heat stasis type thrombotic superficial phlebitis and other vascular diseases.In clinical application，it was found to have a good clinical effect on the treatment of symptoms caused by varicose vein.This paper analyzes the formulation mechanism of Mailuo-Shutong Pill in the treatment of varicocele from the perspective of traditional Chinese and western medicine，and provides theoretical basis for clinical application.