To explore the material basis and action mechanism of Qingfei Paidu Decoction(QFPDT) and coronavirus disease(COVID-19) by using network pharmacology.Methods:The active ingredients，target proteins and related diseases were obtained through TCMSP Database.Uniprot database was used to query the gene names corresponding to the target proteins.Cytoscape 3.7.2 software was used to build a network model of drug active ingredients-potential targets and main targets-related diseases; ClueGo plugin of Cytoscape 3.7.2 software was used to perform GO biological processes on main potential targets and KEGG metabolic pathway analysis.Results:After screening，278 compounds and 177 target proteins regulated by QFPDT were obtained.According to the degree value，the main active ingredients of QFPDT were quercetin，stigmasterol，β-sitosterol and kaempferol.The targets of related diseases were PTGS2，PPARG，MAPK14，and CDK2.The diseases related to COVID-19 pneumonia included inflammation，asthma，lung cancer，fever，and viral infection etc.According to the analysis of GO biological processes and KEGG metabolic pathways，the main pathways of QFPDT action were IL-17 signaling pathway，estrogen signaling pathway，platelet activation pathway，and small cell lung cancer.Conclusion:This paper makes a preliminary prediction of the material basis and mechanism of QFPDT，and provided a basis for QFPDT in the clinical treatment of COVID-19.