To analyze the five-year clinical efficacy and safety of Integrated traditional Chinese and western medicine in the treatment of IgA nephropathy.Methods:A total of 131patients with IgA nephropathy who had been treated for 5 years from January 2002 to December 2012 with complete follow-up data were divided into a TCM treatment group and an integrated traditional Chinese and western medicine treatment group according to the actual medication status.The changes of renal function,24-hour urinary protein and safety indexes were observed before and after treatment.Results:From the baseline,the condition of the integrated traditional Chinese and western medicine group was more serious than that of the traditional Chinese medicine group.For the mild to moderate pathological type(40 cases,accounting for 30.53%),there was no significant change in SCr and URPO inthe two groups before and after treatment.For the moderate to severe type(91 cases,69.47%),UPRO in the integrated traditional Chinese and western medicine group(53 cases) decreased significantly comparing with before(P<0.05).SCr and eGFR did not change significantly(P>0.05).In the traditional Chinese medicine group(38 cases),there was no significant change in all indexes(P>0.05).The 5-year cumulative kidney survival rate of integrated traditional Chinese and western medicine was 97.1%,and that of the traditional Chinese medicine group was 95.2%.There was no significant difference in the survival rate between the two groups(P>0.05).The adverse events in the traditional Chinese medicine group were less than those in the integrated traditional Chinese and western medicine group.Conclusion:Both traditional Chinese medicine and integrated traditional Chinese and western medicine are effective in the treatment of IgA nephropathy.For the severe type of IgA nephropathy,integrated traditional Chinese and western medicine treatment is preferred clinically.Both of the two treatments have a protective effect on long-term renal function,and the traditional Chinese medicine group has fewer side effects and higher safety.