Cardiovascular disease has become one of the leading causes of death worldwide.Among them,the inflammatory response mediated by innate immune response has become the focus of cardiovascular disease research in recent years.TLR4 is a key immune response pathway,which can activate the release of a variety of inflammatory factors,cause inflammation,and play an important role in the occurrence and development of cardiovascular disease.Studies have shown that traditional Chinese medicine has obvious advantages in the prevention and treatment of cardiovascular diseases,and its prevention mechanism may be related to the regulation of TLR4 signaling molecules and the inhibition of inflammatory damage.This paper takes TLR4 signaling pathway as an entry point to explore the mechanism of Chinese medicinal to prevent and treat cardiovascular diseases through TLR4,and provide references for in-depth research on the pathogenesis of cardiovascular diseases and the mechanism of traditional Chinese medicine in preventing and treating cardiovascular diseases.