理气活血类中成药治疗冠心病心绞痛的网状Meta分析
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北京市自然科学基金项目(7202126)


Network Meta-analysis of Chinese Patent Medicines of Regulating Qi and Activating Blood Circulation for Angina Pectoris
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    摘要:

    目的:系统评价理气活血类中成药治疗冠心病心绞痛的有效性。方法:检索国家知识基础设施数据库、中国学术期刊数据库、中文科技期刊数据库、PubMed、Cochrane Library,检索起止时间为建库至2020年7月。筛选出理气活血类中成药治疗冠心病心绞痛的随机对照试验,按照Jadad量表对文献进行质量评价,采用Stata 16和R3.5.1软件进行统计分析。结果:共纳入58个研究,总样本量7 467例,干预措施包括复方丹参片、复方丹参滴丸、速效救心丸、理气活血滴丸、冠心丹参滴丸、心可舒片、血府逐瘀胶囊、银丹心脑通软胶囊共8种理气活血类中成药。结果显示,心绞痛疗效方面,累积概率排序为:速效救心丸(0.815)>复方丹参滴丸(0.804)>银丹心脑通软胶囊(0.801)>冠心丹参滴丸(0.447)>心可舒片(0.444)>血府逐瘀胶囊(0.378)>理气活血滴丸(0.247)>复方丹参片(0.063)。心电图疗效方面,累积概率排序为:速效救心丸(0.790)>冠心丹参滴丸(0.784)>血府逐瘀胶囊(0.734)>理气活血滴丸(0.569)>心可舒片(0.519)>银丹心脑通软胶囊(0.362)>复方丹参滴丸(0.242)>复方丹参片(0.000)。综合2个结局指标,速效救心丸、冠心丹参滴丸、血府逐瘀胶囊疗效较佳。结论:气滞血瘀型心绞痛患者可优选速效救心丸,但受纳入研究质量所限,该结论仍需开展高质量研究进一步验证,并结合具体情况进行选择。

    Abstract:

    To systematically evaluate the efficacy of Chinese patent medicines for regulating qi and activating blood circulation in the treatment of angina pectoris.Methods:China National Knowledge Infrastructure(CNKI),China Science Periodical Database(CSPD),Chinese Citation Database(CCD),PubMed and Cochrane Library were all retrieved from the establishment of the database until July 2020.Randomized controlled trials of Chinese patent medicines for regulating qi and activating blood for the treatment of coronary heart disease and angina pectoris were selected.The quality of the literature was evaluated according to the Jadad scale,and statistical analysis was performed using Stata 16 and R3.5.1 software.Results:A total of 58 studies were included,with a total sample size of 7,467 cases.The measures included 8 Chinese medicines,covering Danshen Tablet(DST),Danshen Dropping Pills(DSDP),Suxiaojiuxin Pills(SXJXP),Liqi Huoxue Pills(LQHXP),Guanxin Danshen Dropping Pills(GXDSP),Xinkeshu Tablets(XKST),Xuefu Zhuyu Capsules(XFZYC)and Yindan Xinnaotong Capsule(YDXNTC).The results showed that in terms of the efficacy of angina pectoris,the cumulative probability ranking was:SXJXP(0.815)>DSDP(0.804)>YDXNTC(0.801)>GXDSP(0.447)>XKST(0.444)>XFZYC(0.378)>LQHXP(0.247)>DST(0.063).In terms of the effective rate of electrocardiogram,the rank of cumulative probability was:SXJXP(0.790)>GXDSP(0.784)>XFZYC(0.734)>LQHXP(0.569)>XKST(0.519)>YDXNTC(0.362)>DSDP(0.242)>DST(0.000).Taking the 2 outcomes into consideration,the effects of SXJXP,GXDSP and XFZYC were better.Conclusion:For patients with angina pectoris caused by qi stagnation and blood stasis,SXJXP can be given preference in clinical.However,in consideration of limited quality of included studies,this conclusion still needs to be further verified by high-quality studies.In addition,we should select Chinese patent medicine in combination with individual situations.

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孙怿泽,王哲义,唐卓然,黄乐曦,赵海滨.理气活血类中成药治疗冠心病心绞痛的网状Meta分析[J].世界中医药,2021,(21).

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  • 收稿日期:2020-12-04
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  • 在线发布日期: 2021-12-07
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