To analyze and summarize the rules of prescriptions for the treatment of scleroderma with Chinese medicine prescriptions based on the data mining method.Methods:Literature on traditional Chinese medicine(TCM) treatment of scleroderma in China National Knowledge Infrastructure，China Science Periodical Database，and Chinese Citation Database was searched to select medical records that meet the inclusion criteria，extract TCM diagnosis，treatment，prescriptions and other information.After standardization，modern mathematical statistics was used to analyze medications rules.Results:A total of 69 literatures were screened and 101 effective medical records were included.The frequency of occurrence of commonly used drugs and drug pairs in medical records and the correlation between commonly used drugs were analyzed，and 16 core combinations composed of 3 to 5 drugs and 8 new prescriptions were obtained.Conclusion:At present，TCM is commonly used to treat scleroderma such as Radix Astragali seu Hedysari，Radix Angelicae Sinensis，Ramulus Cinnamomi and other warm tonics，as well as Caulis Spatholobi，Radix Salviae Miltiorrhizae and other blood-activating drugs.The addition and subtraction of prescriptions has obvious regularity，which can provide theoretical basis for clinical treatment，prescription medication and new drug research and development，etc.