Ulcerative colitis (UC) is one of the refractory diseases in the world,and its etiology and mechanism are not clear.Having a stable animal model is an important link in the study of its etiology and pathogenesis and the prevention and treatment of the disease.Since the development of the animal model of ulcerative colitis,the modeling technology is relatively mature.The existing modeling methods are immune method,chemical stimulation method,compound method,TCM syndrome model,gene modification method,bacterial infection model and spontaneous model.UC is highly similar to the clinical manifestations of the disease of “chronic dysentery” in traditional Chinese medicine.Its main pathogenesis is spleen deficiency and loss of movement of the body,and eating disorders and emotional internal injuries are the primary triggers.Therefore,the establishment of the UC animal model of spleen deficiency is the cornerstone of exploring many TCM syndrome types of UC,so the research progress of UC animal model of spleen deficiency is reviewed,which is convenient for the application and development of researchers.