To explore the mechanism of the Jianpi Yishen Huazhuo Prescription in treatment of post stroke cognitive impairment (PSCI) by using network pharmacology method.Methods:TCMSP,TCMID and ETCM databases were used to screen the active ingredients of the Jianpi Yishen Huazhuo Prescription,and the Swiss Target Prediction database was used to predict the target of the active ingredients.The GeneCards database was used to screen PSCI related disease targets.RStudio software was used to draw the Wien diagram for the common targets of the Jianpi Yishen Huazhuo Formula and PSCI.The PPI analysis,GO enrichment analysis and KEGG enrichment analysis were performed on the 2 common targets through the String and Metascape databases.Cytoscape 3.6.0 was used to draw the network diagram of the Jianpi Yishen Huazhuo Prescription-target point-PSCI-pathway.The AutoDock was used for molecular docking verification of core components and core targets.Results:A total of 39 active ingredients and 553 targets of the Jianpi Yishen Huazhuo Formula were screened out,and the 2305 potential targets of PSCI were screened out,among which the common targets were 254.Through the GO and KEGG enrichment analysis,it was found that the Jianpi Yishen Huazhuo Formula might play a therapeutic effect on PSCI through multiple targets and pathways such as synaptic plasticity,anti-apoptosis and anti-inflammation.The molecular docking results indicated that the active component Stigmasterol had good binding activity with the core target (MAPK1,Src,MAPK3,TP53,HSP90Aa1) and Palmatine had good binding activity with the core target (AKT1).Conclusion:The Jianpi Yishen Huazhuo Formula may play an important role in the treatment of PSCI by regulating synaptic plasticity,anti-apoptosis and anti-inflammation.