To analyze the active components of Danggui Huoxue Decoction in the treatment of arteriosclerosis obliterans（ASO） of the lower extremities and the pharmacological effect of its target.Methods:By TCMSP database，we screened the effective active ingredients and targets of Danggui Huoxue Decoction and we used GeneCard and OMIM database to obtain lower limb ASO-related proteins; we used String platform to construct PPI network for drug-disease target proteins，and used DAVID database to obtain Danggui Huoxue Decoction-lower ASO target for GO function and KEGG pathway enrichment analysis.Results:Danggui Huoxue Decoction had 234 active ingredients，and Danggui Huoxue Decoction-lower limb ASO had 26 targets; In PPI interaction network analysis it was found that IL-6，VEGFA，MMP-9，IL-10，etc.may be the treatment of Danggui Huoxue Decoction for the key target of ASO.A total of 46 GO biological processes and 167 related signal pathways were obtained，of which HIF-1，AGE-RAGE，IL-17，TNF and other signal pathways were closely related to the treatment of lower extremity ASO.Conclusion:Based on network pharmacology，the target network of the main components of Danggui Huoxue Decoction and its mechanism of action in the treatment of lower limb ASO are explored，which provides new ideas and scientific basis for further basic experimental research on this disease.