To explore the ingredients，targets and mechanism of Taohe Chengqi Decoction(TCD) on endometriosis by network pharmacology.Methods:The active ingredients of Taohe Chengqi Decoction were collected through the database，its targets were obtained，and we combined with the targets of endometriosis to construct a network of “Taohe Chengqi Decoction Components Targets-Endometriosis Targets”，and analyzed them to obtain a common target.By comparing with FDA drug targets，we analyzed the diseases that a common target may treat，and constructed a “key target-disease” network.Then，the common target was analyzed for GO and KEGG pathways.Finally，the active ingredients were molecularly docked with key targets.Results:A total of 114 TCD active ingredients，236 targets and 401 endometriosis targets were collected.From those，48 common targets were screened.There were 29 key targets between the common targets and 1215 FDA drug targets，which were associated with 56 diseases，including endometriosis.In GO enrichment analysis，common targets were closely related to extracellular matrix，cell membrane and DNA binding.It involved in many biological processes，for example the positive regulation of RNA polymerase，transcription process，and the positive regulation of ERK1/2 pathway.KEGG pathway analysis showed that common targets were involved in 63 pathways，including rheumatoid arthritis，TNF，estrogen and VEGF，etc.It was found in molecular docking that there were 8 active ingredients of TCD were successfully binding with 5 common targets，especially licoisoflavone and quercetin.Conclusion:This study preliminarily reveals the mechanism of TCD on endometriosis，which is beneficial for its further research and development.