To explore the potential molecular mechanism of Jingzhi Kesou Tanchuan Pills in the treatment of COVID-19 based on network pharmacology and molecular docking.Methods:We obtained the active compounds and potential targets in Jingzhi Kesou Tanchuan Pill by searching TCMATCOV V1.0 database.The enrichment analysis of GO and KEGG was performed by R language software.Cytoscape 3.6.1 software was used to construct the compound-target network and the essential compound-target-pathway network.AutoDock was applied to acquire the molecular docking result of active components and core targets.Results:The active compounds of Jingzhi Kesou Tanchuan Pills mainly acted on 32 targets，including TNF,IL-10,IL-6,IL-2,CCL2,CCL3,TLR7,LFNG,which involved in regulating Cytokine-cytokine receptor interaction pathway,T cell receptor signaling pathway,IL-17 signaling pathway,C-type lectin receptor signaling pathway,JAK-STAT signaling pathway,Toll-like receptor signaling pathway,Th17 cell differentiation,TNF signaling pathway and other signaling pathways that may be related to the treatment of COVID-19.The results of molecular docking revealed that glycyrrhetinic acid and piperitenone had better spontaneous binding effect with the key target.Conclusion:This study preliminarily explore the mechanism of multiple components,multiple targets,multiple pathways of Jingzhi Kesou Tanchuan Pills in the treatment of COVID-19 by network pharmacology.