To explore the network pharmacology mechanism of Xiaoer Huadu Powder in the treatment of upper respiratory tract infection.Methods:We screened the main chemical components of Xiaoer Huadu Powder from TCMSP database and collect potential targets; screened human upper respiratory tract infection disease targets from GeneCards database,OMIM database and TTD database; used online programs to drawy Venny diagrams and obtain pediatrics.The common target of Xiaoer Huadu Powder and upper respiratory tract infection,Cytoscape software were used to construct a network diagram of “Chinese medicine-important active ingredients-disease targets”; the STRING platform was used to construct the protein-protein interaction(PPI) network diagram display; the DAVID platform was used for GO function enrichment.We set analysis and KEGG pathway analysis; application of molecular docking to visualize compound-target.Results:A total of 131 effective compounds and 107 corresponding targets were screened out from Xiaoer Huadu Powder,7 339 related disease targets were screened out from upper respiratory tract infection,and 92 common targets were obtained.30 go entries and 46 KEGG signaling pathways were obtained after enrichment analysis.A total of 3 key compounds and one target were obtained by molecular docking.Conclusion:Xiaoer Huadu Powder in the treatment of upper respiratory tract infection may exert its therapeutic effect on upper respiratory tract infection through its key components quercetin,baicalein and isorhamnetin acting on IL6、HIF1A target proteins,regulating inflammatory response,control hypoxia mechanism.