To analyze the current research status of atherosclerosis in animal experiments and seek a recognized method for modeling.Methods:The CNKI database was searched for the literature on atherosclerosis-related animal experiments in the past ten years,and analyzed according to the publication time,type of publication,document source,type of model animal,modeling method,modeling time,and related treatment methods.Results:A total of 2 709 papers were included,1) 2 173 papers related to the treatment of atherosclerosis; 2) The publishing trend was generally stable; 3) Model animals were ApoE-/-mice,SD rats,and New Zealand rabbits.Mainly,the main modeling methods were simple high-fat diet feeding,high-fat diet+intraperitoneal injection of vitamin D3,high-fat diet+balloon injury; 4) Animal experiments on the treatment of atherosclerosis with traditional Chinese medicine have been widely carried out.Conclusion:At present,the most involved animal model is ApoE-/-mice.The model is made by feeding pure high-fat diet.The modelling time is concentrated at about 12 weeks,and the research on atherosclerosis in Chinese medicine has been deeply carried out,which laid the foundation for wide application in clinic.