To explore the potential molecular mechanism of Xihuang Pills in preventing and treating non-small cell lung cancer(NSCLC) by means of network pharmacology and molecular docking.Methods:The effective active components and targets of Xihuang Pills were screened and analyzed in TCM MSP and BATMAN-TCM database.We searched the related targets of NSCLC in GeneCards database and OMIM database，and selected the intersection target with Xihuang Pills as the research target.Protein-protein interaction network diagram was constructed by using STRING database.The network diagram of drug-target-disease visual interaction was constructed by using Cytoscape 3.7.0 software.GO function enrichment analysis and KEGG pathway enrichment analysis were carried out on the selected key targets by using DAVID data.Finally，the effective active ingredients and key targets of drugs were verified by molecular docking with AutoDock Vina software and Pymol software.Results:A total of 51 main active components of Xihuang Pills were screened，including quercetin，β-sitosterol，etc.Among them，there were 178 targets acting on NSCLC，and the key targets were MAPK1，JUN，AKT1，TP53，RELA，etc.GO and KEGG analysis showed that the mechanism of Xihuang Pills in treating NSCLC involved many biological processes and PI3K-Akt signal pathway，MAPK signal pathway，TNF signal pathway and other signal transduction pathways.The active ingredients of medicine had good docking activity with key targets.Conclusion:Network pharmacological analysis shows that Xihuang Pills is a multi-component，multi-target，multi-channel synergistic effect in the treatment of NSCLC，which provides sufficient theoretical basis for subsequent related experiments.