To predict the active chemicals and targets on childhood asthma and explore the mechanism of Mahuang Fuzi Xixin decoction.Methods:Based on TCMSP and Genecards database，the active chemicals and chemicals-targets were gathered.Then drug-chemicals-targets network and PPI network were performed utilizing string database and Cytoscape software.Finally，GO and KEGG enrichment analysis were carried out by using Cluster Profiler package in R RStudio software.Results:With the setting of OB≥30% and DL≥0.18，35 active chemicals were gathered，including quercetin，luteolin,(+)-catechin and so on and 171 targets(JUN，AKT1，MAPK1，MAPK3，RELA，IL6,etc）were fished out.GO and KEGG pathways were gathered and analysed，including TNF signaling pathway，AGE-RAGE signaling pathway，IL-17 signaling pathway，HIF-1 signaling pathway and so on.Conclusion:Mahuang Fuzi Xixin Decoction may play a role in treating childhood asthma，inhibiting the expression of inflammatory factors and improving tracheal obstruction，through regulating multiple components，multiple targets，multiple signaling pathways.