To evaluate the efficacy of Sijunzi Decoction in the treatment of ulcerative colitis(UC).Methods:A total of 7 commonly used medical databases were searched by computer，and the randomized controlled trials of Sijunzi Decoction in the treatment of UC were collected，all of which were built from March to March 2020，and then the data were collected and analyzed.Results:A total of 22 studies were included，including 1862 patients.The results of Meta analysis showed that compared with conventional Western medicine，the prescription with Sijunzi Decoction as the basic prescription could improve the curative effect of endoscope ［(OR=3.76,95%CI(2.83 to 5.00)，P<0.000 01］ and the curative effect of traditional Chinese medicine symptoms ［(OR=3.08,95%CI(1.21 to 7.87)，P=0.02］，improve the expression of serum tumor necrosis factor-α ［MD=-5.21,95%CI(-6.86 to -3.56)，P<0.000 01］，the expression of serum interleukin-33 ［MD=-1.10,95%CI(-1.28 to -0.92),P<0.000 01］，the expression of serum superoxide dismutase ［MD=107.64,95%CI(84.14 to 131.14)，P<0.000 01］，and reduce the incidence of adverse reactions ［(OR=0.37，95%CI(0.15 to 0.94)，P=0.04］.Conclusion:Sijunzi Decoction as the basic prescription in the treatment of ulcerative colitis can significantly improve the clinical efficacy，improve the expression of serum inflammatory mediators and superoxide dismutase,and has high safety.