To analyze and summarize the acupoint selection rules in acupuncture treatment of hyperlipidemia by data mining technology.Methods:National Knowledge Infrastructure Database(CNKI)，China Academic Journals Database(CSPD)，Chinese Sci-tech Journals Database(CCD)，Pubmed were searched for acupuncture treatment of hyperlipidemia from January 1，1990 to December 31，2020.Establish acupuncture prescription database was established，SPSS 20.0，SPSS Modeler 18.0 software were used to carry out statistical analysis，and explore the rules of selection of acupoints.Results:A total of 134 papers were included in this analysis，involving 177 acupuncture prescriptions and 88 acupoints.The total frequency of these acupoints was 1207 times，and the top 10 acupoints in use frequency were Zusanli(ST36)，Fenglong(ST40)，Sanyinjiao(SP6)，Zhongwan(CV12)，Pishu(BL20)，Tianshu(ST25),Yinlingquan(SP9)，Taixi(KI3)，Shenshu(BL23) and Taibai(SP3) in order.The often selected meridians were stomach meridian，spleen meridian，bladder meridian; the acupoints located at the lower limbs，chest and abdomen were used more; he points，front-mu points and crossing points in the specific acupoints were commonly selected; eight groups of strongly correlated acupoints were obtained by correlation analysis，among which Zusanli(ST36)-Sanyinjiao(SP6) was the most frequently used; four acupoint clusters were obtained by cluster analysis.Conclusion:Acupuncture treatment of hyperlipidemia is mainly based on the spleen，with regulating the spleen and stomach functions as the core，and Zusanli(ST36)，Fenglong(ST40) and Sanyinjiao(SP6) as the core acupoints，Acupoints are selected according to syndromes，combinations of inner and outer meridians，distance，and anteroposterior.