To analyze the clinical papers on the treatment of moxibustion in the recent 10 years and discuss the relevant disease spectrum and indications.Methods:CNKI，CCD，CSPD，SinoMed，PubMed，Web of Science，and Cochrane Library were searched for the clinical papers on moxibustion from October 1st，2011 to October 31st，2021，for the establishment of an information database.After collation，sorting，analysis，and summary，the disease spectrum of moxibustion and indications for treatment were obtained.Results:A total of 1 822 papers were included.The clinical application of moxibustion in the past decade covered 19 clinical categories，including orthopedics，gastroenterology，obstetrics，gynecology，and immunology，with 197 diseases involved.Orthopedics had the largest number of papers and diseases under investigation，followed by gastroenterology，obstetrics，and gynecology.After screening，28 types of indications of moxibustion were obtained，involving nine first-level ones.A total of 1 804 papers explicitly clarified the use of moxibustion to treat the diseases，while 18 papers used non-moxibustion therapies.Moxibustion with moxa sticks was the most frequently used.Conclusion:As revealed by results，197 types of diseases were treated by moxibustion alone in the past decade，and the number of orthopedic diseases was the largest.The first-level indications were abundant in orthopedics and immunology.Moxibustion with moxa sticks was the most widely used.In the follow-up research，multi-disciplinary techniques and methods should be adopted to carry out in-depth standardized studies on moxibustion materials，moxibustion temperature，and moxibustion quantity to standardize the clinical application of moxibustion.